Updated 2025-12-22

Best NMN Supplements 2025

We tested 9 NMN supplements for purity, effectiveness, and value. Here are our expert rankings to help you find the right NAD+ booster for your longevity goals.

Lab-Tested
Expert Reviewed
Independent Research

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What is NMN and Why Does It Matter?

NMN (Nicotinamide Mononucleotide) is a naturally occurring molecule that serves as a direct precursor to NAD+ (nicotinamide adenine dinucleotide), one of the most critical coenzymes in your body. NAD+ is essential for cellular energy production, DNA repair, and activating longevity-related genes called sirtuins.

The problem? NAD+ levels decline by up to 50% by age 50, and this decline is linked to virtually every hallmark of aging: reduced energy, slower metabolism, impaired cognitive function, and decreased cellular repair capacity.

NMN supplementation offers a direct route to restore NAD+ levels. Human clinical trials have demonstrated that NMN can safely increase NAD+ levels within weeks of supplementation.

Want to learn more? Read our comprehensive guide to NMN or compare NMN vs NR.

NMN Supplement Comparison Table

Rank Product Score Price Best For Details
1
ProHealth NMN Pro 500
ProHealth Longevity
BEST OVERALL
8.5 /10
$59.99 NAD+ restoration for ages 40+ Read Review
2
DoNotAge NMN Powder
DoNotAge
EDITOR'S CHOICE
8.4 /10
$39.99 Budget-conscious biohackers seeking maximum value Read Review
3
Thorne NicotinamidePro
Thorne
8.4 /10
$55.00 Quality-focused users Read Review
4
Alive By Science Sublingual NMN
Alive By Science
8.3 /10
$64.99 Biohackers seeking maximum NMN bioavailability Read Review
5
Renue By Science Liposomal NMN
Renue By Science
8.2 /10
$64.95 Those prioritizing bioavailability Read Review
6
Wonderfeel Youngr NMN
Wonderfeel
8.2 /10
$88.00 Users seeking comprehensive all-in-one longevity formula Read Review
7
OMRE NMN + Resveratrol
OMRE
8.0 /10
$47.00 Users wanting NMN + resveratrol combination Read Review
8
Quicksilver Scientific NAD+ Gold
Quicksilver Scientific
8.0 /10
$75.00 Those prioritizing absorption Read Review
9
Cymbiotika Liposomal NMN
Cymbiotika
7.9 /10
$77.77 Users preferring liquid over capsules/powder Read Review

Our Top NMN Supplement Picks for 2025

#1 BEST OVERALL EDITOR'S CHOICE

ProHealth NMN Pro 500

by ProHealth Longevity

ProHealth NMN Pro 500 review: Expert analysis of this high-purity NMN supplement with clinical research, effectiveness data, safety profile, and real ...

8.5
Effectiveness
9.0
Safety
8.0
Value
9.0
Quality
8.0
Research

Pros

  • + Exceptional 99.8% purity with third-party verification
  • + High-potency 500mg dose per capsule (vs 300mg competitors)
  • + Pharmaceutical-grade manufacturing standards

Cons

  • - Fewer human clinical studies than established NR products
  • - No FDA GRAS status (common for NMN supplements)
  • - Lacks NSF Certified for Sport testing
8.5
out of 10
Starting at
$59.99
Check Price Full Review
#2 EDITOR'S CHOICE

DoNotAge NMN Powder

by DoNotAge

DoNotAge NMN powder review: Expert analysis of this high-purity, affordable NMN supplement with clinical research backing, effectiveness data, and rea...

8.5
Effectiveness
8.5
Safety
9.5
Value
8.0
Quality
7.5
Research

Pros

  • + Exceptional value at $0.20 per 500mg serving (best in category)
  • + High purity testing (99%+ verified by third-party labs)
  • + European brand with strict quality standards

Cons

  • - Powder requires measuring with included scoop (less convenient than capsules)
  • - Bitter taste may be unpleasant for some users
  • - No enteric coating (potential stomach acid degradation)
8.4
out of 10
Starting at
$39.99
Check Price Full Review
#3

Thorne NicotinamidePro

by Thorne

In-depth review of Thorne NicotinamidePro NMN. Analysis of quality, effectiveness, and whether the premium pricing is justified....

8.5
Effectiveness
9.0
Safety
7.0
Value
9.5
Quality
8.0
Research

Pros

  • + Exceptional quality standards (NSF Certified for Sport, TGA Listed)
  • + Trusted brand with excellent reputation
  • + Third-party tested for purity and potency

Cons

  • - Premium pricing at over $2 per serving
  • - Lower dose per capsule requires multiple capsules for higher doses
  • - Limited to one size option
8.4
out of 10
Starting at
$55.00
Check Price Full Review
#4

Alive By Science Sublingual NMN

by Alive By Science

Alive By Science NMN review: Expert analysis of sublingual NAD+ booster with innovative delivery, liposomal options, effectiveness, safety data, and r...

9.0
Effectiveness
8.5
Safety
7.5
Value
8.5
Quality
8.0
Research

Pros

  • + Sublingual delivery bypasses digestive system for superior absorption
  • + Liposomal option available for maximum bioavailability
  • + Multiple NMN forms: standard, sublingual, liposomal, transdermal

Cons

  • - Higher price point than standard NMN capsules
  • - Sublingual tablets have distinct taste (slightly bitter)
  • - Requires refrigeration after opening for optimal stability
8.3
out of 10
Starting at
$64.99
Check Price Full Review
#5

Renue By Science Liposomal NMN

by Renue By Science

Renue By Science NMN review: Expert analysis of this liposomal NMN supplement with enhanced bioavailability, effectiveness data, and real results....

8.5
Effectiveness
8.5
Safety
7.5
Value
8.5
Quality
8.0
Research

Pros

  • + Liposomal delivery for enhanced absorption
  • + Third-party tested for purity (99%+)
  • + Multiple delivery formats available

Cons

  • - Higher cost per serving than powder forms
  • - Lower dosage per serving (250mg vs 500mg)
  • - Limited long-term human studies
8.2
out of 10
Starting at
$64.95
Check Price Full Review
#6

Wonderfeel Youngr NMN

by Wonderfeel

Wonderfeel Youngr NMN review: Expert analysis of this complete longevity formula combining NMN, resveratrol, ergothioneine, and vitamin D3 for compreh...

8.5
Effectiveness
8.5
Safety
7.0
Value
8.5
Quality
8.0
Research

Pros

  • + Complete longevity formula (NMN + resveratrol + ergothioneine + D3)
  • + Formulated by Dr. Andrew Salzman (Harvard-trained physician)
  • + High-dose 900mg NMN per daily serving

Cons

  • - Premium pricing at $88/month (highest in category)
  • - Lower individual ingredient doses than standalone products
  • - Newer brand with limited long-term track record
8.2
out of 10
Starting at
$88.00
Check Price Full Review
#7

OMRE NMN + Resveratrol

by OMRE

OMRE NMN + Resveratrol review: Expert analysis of this combination supplement that mirrors Dr. David Sinclair's longevity protocol with clinical resea...

8.0
Effectiveness
8.5
Safety
8.0
Value
8.0
Quality
7.5
Research

Pros

  • + Combines NMN and resveratrol (mirrors Sinclair protocol)
  • + Excellent value for combination product ($47/month)
  • + Third-party tested for purity and potency

Cons

  • - Newer brand with less established track record
  • - Lower individual doses than standalone products
  • - Limited company transparency and history
8.0
out of 10
Starting at
$47.00
Check Price Full Review
#8

Quicksilver Scientific NAD+ Gold

by Quicksilver Scientific

Quicksilver Scientific NAD+ Gold review: Expert analysis of this advanced liposomal NAD+ supplement with NMN and TMG for cellular support....

8.5
Effectiveness
8.0
Safety
7.0
Value
8.5
Quality
8.0
Research

Pros

  • + Advanced liposomal delivery technology
  • + Combines NMN with TMG (trimethylglycine)
  • + Liquid format for flexible dosing

Cons

  • - Premium pricing (highest in category)
  • - Taste may not appeal to everyone
  • - Requires refrigeration after opening
8.0
out of 10
Starting at
$75.00
Check Price Full Review
#9

Cymbiotika Liposomal NMN

by Cymbiotika

Cymbiotika NMN review: Expert analysis of this premium liposomal liquid NMN supplement with enhanced absorption technology, effectiveness data, and re...

8.0
Effectiveness
8.0
Safety
6.5
Value
8.5
Quality
8.0
Research

Pros

  • + Liposomal delivery system for enhanced absorption
  • + Pleasant taste compared to powder NMN
  • + Premium Miron glass packaging protects formula

Cons

  • - Premium pricing at $77.77/month (expensive)
  • - Lower NMN dose (400mg) than competitors
  • - Small serving size may feel insufficient
7.9
out of 10
Starting at
$77.77
Check Price Full Review

How We Test NMN Supplements

Our rankings are based on rigorous evaluation across five key criteria. Each supplement is scored on a 0-10 scale, with the overall score being a weighted average. Learn more about our complete testing methodology.

Effectiveness

Does the supplement actually work? We evaluate published clinical research, NAD+ elevation data, and user-reported outcomes.

Safety

We review safety studies, adverse event reports, and third-party testing for contaminants and purity verification.

Value

Cost per effective dose, subscription options, and overall value compared to similar products in the market.

Quality

Manufacturing standards, GMP certification, purity levels, and formulation quality including stability.

Research Backing

Quantity and quality of peer-reviewed studies, clinical trials, and scientific evidence supporting the specific formulation.

What to Look for in NMN Supplements

With dozens of NMN supplements on the market, choosing the right one can be overwhelming. Here are the key factors we recommend evaluating:

1. Purity and Third-Party Testing

Look for NMN supplements with at least 99% purity verified by independent third-party laboratories. Reputable brands provide Certificates of Analysis (CoA) showing testing results for purity, heavy metals, and contaminants.

Why it matters: Lower purity means you're getting less active NMN and potentially more impurities. Research shows that purity significantly affects efficacy.

2. Dosage and Form

Most clinical studies use 250-500mg daily. Consider whether you prefer capsules (convenient) or powder (flexible dosing, better value).

Sublingual options: Some brands offer sublingual tablets that may improve absorption by bypassing digestive degradation.

3. Stability and Storage

NMN can degrade with exposure to heat and moisture. Look for stabilized formulations like Uthever NMN that have documented stability data. Some products require refrigeration after opening.

Pro tip: Check the manufacturing date and expiration. Fresh NMN within its shelf life delivers optimal potency.

4. Brand Reputation

Choose brands with a track record in longevity supplements, GMP-certified manufacturing facilities, and transparent business practices. Avoid no-name brands selling through unknown channels.

Red flags: Unrealistic claims, no contact information, missing CoA documentation, suspiciously low prices.

5. Value Per Serving

Calculate the cost per effective dose (typically 500mg). Bulk powder typically offers the best value, while capsules and sublingual forms cost more for convenience.

Value leaders: DoNotAge NMN Powder offers excellent value at approximately $0.20 per 500mg serving.

Scientific Resources

For deeper research into NMN and NAD+ science, we recommend these peer-reviewed sources:

Frequently Asked Questions

What is the best NMN supplement in 2025?

Based on our comprehensive testing, ProHealth NMN Pro 500 ranks as the best overall NMN supplement in 2025, scoring 8.5/10 for its exceptional 99.8% purity, high-potency 500mg dosing, and pharmaceutical-grade Uthever NMN formula. For budget-conscious buyers, DoNotAge NMN Powder offers the best value at just $0.20 per serving.

How much NMN should I take daily?

Most clinical studies use 250-500mg of NMN daily. Beginners should start with 250mg and may increase to 500-1000mg based on individual response. NMN is typically taken in the morning with or without food. Some researchers like Dr. David Sinclair take higher doses (1g+), but clinical evidence supports the 250-500mg range for most people.

Is NMN better than NR for boosting NAD+?

Both NMN and NR (nicotinamide riboside) effectively boost NAD+ levels. NMN is one biochemical step closer to NAD+ in the conversion pathway and may offer faster absorption via the Slc12a8 transporter. NR has more published human clinical trials. Both are effective choices for NAD+ optimization. Read our detailed NMN vs NR comparison for a full breakdown.

Are NMN supplements safe?

NMN has shown an excellent safety profile in clinical studies. Human trials at doses up to 1200mg daily have reported no serious adverse effects. Minor side effects may include mild digestive discomfort in some users. However, NMN is not FDA-approved as a drug, and pregnant or breastfeeding women should avoid supplementation. Always consult your healthcare provider before starting any new supplement regimen.

How long does it take for NMN to work?

Most users report increased energy within 2-4 weeks of starting NMN supplementation. Deeper cellular benefits like improved metabolic function and DNA repair mechanisms may take 8-12 weeks to manifest. Individual responses vary based on age, baseline NAD+ levels, dosage, and overall health status.

What should I look for when buying NMN supplements?

Key factors include: purity (99%+ is ideal), third-party testing certificates, brand reputation, manufacturing standards (GMP certification), stable formulation, and transparent dosing. Avoid products without purity verification or from unknown manufacturers. See our detailed buyer's guide above.

Related Guides and Reviews

What is NMN?

Complete beginner's guide to nicotinamide mononucleotide and how it works.

NMN vs NR Comparison

Detailed comparison of the two most popular NAD+ precursors.

How to Boost NAD+

Complete guide to increasing NAD+ levels through supplements and lifestyle.

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Disclaimer: This page contains affiliate links. We may earn a commission when you purchase products through our links at no additional cost to you. All rankings are based on thorough research and independent testing. NMN supplements are not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any supplement regimen. Read our full disclosure and medical disclaimer.