Senolytic Supplements

Senolytic supplements represent one of the most promising frontiers in longevity research. Senescent cells, often called "zombie cells," are damaged cells that stop dividing but refuse to die. Instead, they secrete inflammatory compounds (the SASP) that accelerate aging and damage surrounding healthy tissue. Senolytic compounds like fisetin, quercetin, and theaflavins can selectively trigger apoptosis (programmed cell death) in these problematic cells while leaving healthy cells unharmed. Unlike daily supplements, senolytics are typically used intermittently—often 2-3 consecutive days per month—because their effects persist after senescent cells are cleared. Research from the Mayo Clinic and other institutions has shown senolytics can reduce biological age markers, improve physical function, and potentially extend healthspan. When choosing senolytic supplements, consider the research backing specific compounds, proper dosing protocols, and whether combination formulas might provide synergistic benefits.

What to Look For When Choosing Senolytic Supplements

• Research-backed compounds (fisetin, quercetin)
• Appropriate dosing for senolytic protocols
• Intermittent dosing guidance
• Combination formulas for synergy