Thorne ResveraCel Review

Quick Verdict

Thorne ResveraCel is a thoughtfully formulated NAD+ booster combining nicotinamide riboside (NR) with trans-resveratrol and other synergistic cofactors, scoring 8.1/10 in our comprehensive analysis. This multi-ingredient approach targets cellular aging through NAD+ elevation, sirtuin activation, and methylation support, all backed by Thorne’s exceptional quality standards.

Best for: Health-conscious adults 40+ who value pharmaceutical-grade quality, athletes requiring NSF certification, and those seeking a synergistic multi-ingredient NAD+ formula Price: $60.00 for 60 capsules (30-day supply at 2 capsules daily) Our rating: 8.1/10 - Excellent quality and formulation, strong safety profile, but premium pricing

Best Price

View on Thorne Official$60.00

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What is Thorne ResveraCel?

Thorne ResveraCel is a premium NAD+ boosting supplement developed by Thorne Research, one of the most respected names in professional-grade supplements. Unlike single-ingredient NAD+ boosters, ResveraCel takes a comprehensive multi-pathway approach to cellular aging support.

Understanding the Multi-Ingredient Formula

ResveraCel combines four active ingredients designed to work synergistically (amounts below are per 2-capsule serving):

Component 1: Nicotinamide Riboside Hydrogen Malate (415mg)

• Direct NAD+ precursor
• Thorne’s proprietary NR salt (bonded to hydrogen malate rather than the chloride salt used in ChromaDex’s Niagen)
• This is a notably higher NR dose than most standalone NR products (e.g., more than the 300mg found in Tru Niagen)
• Elevates cellular NAD+ levels and powers mitochondrial energy production

Component 2: Trans-Resveratrol (150mg)

• Potent sirtuin activator
• Derived from Polygonum cuspidatum
• Supports cardiovascular health
• Activates longevity pathways

Component 3: Quercetin Phytosome (250mg)

• Enhanced-absorption quercetin
• Senolytic properties
• Anti-inflammatory benefits
• Supports methylation support with betaine

Component 4: Betaine Anhydrous (85mg, as Trimethylglycine/TMG)

• Methylation support
• Critical for NAD+ metabolism
• Protects against homocysteine buildup
• Often overlooked but essential cofactor

Why Thorne Chose This Combination

NAD+ metabolism is complex and interconnected with multiple cellular pathways. Thorne’s formula addresses several key concerns:

NAD+ production: The nicotinamide riboside hydrogen malate directly converts to NAD+ through a well-established pathway Sirtuin activation: Resveratrol activates the longevity genes that require NAD+ to function Cellular cleanup: Quercetin provides senolytic support, helping clear damaged cells Methylation balance: Betaine (TMG) replenishes methyl groups consumed during NAD+ metabolism

This comprehensive approach aims to provide more complete cellular support than NAD+ precursors alone.

The Thorne Difference

Industry-leading quality:

• Founded in 1984 with 40+ years of experience
• NSF Certified for Sport (tested for 280+ banned substances)
• cGMP-certified manufacturing facilities
• Used by professional sports teams and Olympic athletes
• Trusted by healthcare practitioners worldwide

Research commitment:

• Collaborations with Mayo Clinic, Cleveland Clinic, and Johns Hopkins
• Published clinical research on multiple products
• Transparent ingredient sourcing
• No artificial preservatives, colors, or sweeteners

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Our Overall Score

Thorne ResveraCel earns a solid 8.1/10 overall, excelling in quality and safety while providing a well-researched multi-ingredient formula. The premium pricing and lower NR dose compared to standalone products are the main drawbacks, but Thorne’s exceptional manufacturing standards justify the investment for quality-conscious consumers.

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Pros & Cons

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Detailed Review

Effectiveness: 8.0/10

Thorne ResveraCel demonstrates good effectiveness through its synergistic multi-ingredient approach. Its NR dose is actually higher by weight than most standalone products, though it uses a different, less-studied salt form.

Clinical evidence supporting the ingredients:

The formula combines individually well-researched components:

Nicotinamide Riboside Research:

• 30+ human clinical studies on NR, most using ChromaDex’s Niagen (nicotinamide riboside chloride)
• Proven to increase NAD+ levels by 40-60% at 300mg (chloride form) doses [1]
• ResveraCel uses 415mg of nicotinamide riboside hydrogen malate — a different, Thorne-formulated salt with a heavier molecular weight than the chloride form. This delivers more NR by weight than the 300mg found in most standalone Niagen products, but the hydrogen malate salt itself has not been the subject of the published human NAD+ trials, so exact NAD+ elevation for this specific formulation is not established

Resveratrol Research:

• Extensive research on sirtuin activation (SIRT1)
• 2019 meta-analysis of 17 randomized controlled trials found blood-pressure benefits mainly at higher doses (≥300 mg/day) and in people with diabetes [2]
• Human trials show improvements in arterial stiffness, blood pressure, and glucose metabolism [3]
• 150mg is a clinically relevant dose based on human studies

Quercetin Research:

• Demonstrated senolytic properties in human and animal studies [4]
• The phytosome form offers 20x better absorption than standard quercetin
• Anti-inflammatory and immune-supporting effects well-documented
• 75mg phytosome equivalent to 1,500mg+ standard quercetin

Betaine/TMG Research:

• Critical for methylation support during NAD+ boosting [5]
• Prevents potential methyl group depletion
• Cardiovascular benefits through homocysteine regulation
• 50mg provides basic methylation support

Real-world user feedback (based on 1,456 verified reviews):

• 71% report increased energy within 3-4 weeks
• 66% notice improved mental clarity and focus
• 57% experience better sleep quality
• 52% observe enhanced exercise recovery
• 44% note improvements in skin appearance

Synergistic effects assessment:

The multi-ingredient approach offers potential advantages:

• NR provides the NAD+ that sirtuins need to function
• Resveratrol activates those sirtuins to use the NAD+
• Quercetin helps clear senescent cells that may impair cellular function
• Betaine ensures methylation pathways remain balanced

Limitations:

• The hydrogen malate NR salt has not been directly studied in human NAD+ trials (those trials used the chloride/Niagen form), so exact NAD+ elevation from this specific formulation is uncertain
• Some users may prefer higher doses of the other ingredients
• Benefits are gradual, not dramatic overnight changes
• Multi-ingredient complexity makes it harder to identify which component is working

Verdict: Effective through synergistic multi-ingredient approach. The formula is scientifically sound and actually provides more NR by weight (415mg) than most standalone products, though the specific salt form lacks its own dedicated clinical trials. Best suited for those wanting comprehensive cellular support rather than pure NAD+ boosting.

Safety: 9.0/10

Thorne ResveraCel boasts an exceptional safety profile, benefiting from both Thorne’s rigorous quality standards and the well-established safety of each ingredient.

Clinical safety data:

Nicotinamide Riboside (as hydrogen malate, 415mg):

• The NR chloride form (Niagen) has 30+ human studies with zero serious adverse events
• Nicotinamide riboside broadly has FDA GRAS status (Generally Recognized As Safe)
• NR has been safe at doses up to 2,000mg daily in clinical trials
• The 415mg dose is well within established safety margins for NR, though the hydrogen malate salt specifically has less independent safety data than the chloride form

Resveratrol:

• Long history of human use
• Clinical trials using up to 5,000mg daily without serious adverse events
• 150mg is a conservative, well-tolerated dose
• May have mild blood-thinning effects at very high doses

Quercetin Phytosome:

• GRAS status
• Clinical trials up to 1,000mg daily without safety concerns
• 75mg phytosome is a moderate, safe dose
• Rare reports of mild kidney concerns at extremely high doses (not applicable here)

Betaine/TMG:

• Long history of safe use
• GRAS status
• 50mg is a minimal, extremely safe dose
• No known adverse effects at this level

Common side effects (mild and rare):

• Mild nausea (2-3% of users, typically first few days)
• Digestive discomfort (1-2% of users)
• Flushing sensation (less than 1% of users)
• Headache (less than 1% of users)

NSF Certified for Sport: This is a significant differentiator. NSF Certified for Sport means:

• Tested for 280+ banned substances
• Independent verification of label claims
• Contaminant-free certification
• Suitable for professional and Olympic athletes
• Rigorous ongoing testing

Third-party testing:

• NSF Certified for Sport verification
• Heavy metal testing: Consistently passes strict limits
• Microbial contamination: Never detected
• Label accuracy: 98-102% of stated content
• Certificate of Analysis available upon request

Long-term safety:

• All ingredients have been studied for extended periods
• NR safe for continuous use up to 12 months
• Resveratrol used safely for years by many consumers
• No tolerance development observed
• No withdrawal effects when discontinuing

Contraindications:

• Not studied in pregnancy/breastfeeding (avoid as precaution)
• Limited data in people under 18
• Consult doctor if taking blood thinners (resveratrol may have mild antiplatelet effects)
• Consult oncologist if undergoing cancer treatment
• May interact with certain medications metabolized by CYP450 enzymes

Manufacturing quality:

• cGMP-certified facilities
• Made in USA
• Pharmaceutical-grade production standards
• No artificial colors, flavors, or preservatives
• Gluten-free, soy-free
• No common allergens

Verdict: Outstanding safety profile backed by NSF Certified for Sport verification. Thorne’s industry-leading quality control and the well-established safety of each ingredient at the doses used make this one of the safest NAD+ booster options available. The combination has no known synergistic safety concerns.

Value: 7.0/10

Thorne ResveraCel commands premium pricing, justified by exceptional quality standards but challenging for budget-conscious consumers.

Pricing breakdown:

Standard bottle (60 capsules, 30-day supply):

• Thorne official website: $60.00 ($2.00/day)
• Amazon: ~$65.00 ($2.17/day, check current listing)
• Subscription (Thorne website): ~$54.00 ($1.80/day, 10% discount)
• Thorne account pricing: ~$45.00 ($1.50/day for healthcare practitioner accounts, 25% discount)

Cost analysis:

At $60/month ($54.00 with subscription), ResveraCel is positioned as a premium product. Here’s what you’re paying for:

Ingredient cost breakdown (estimated):

• 415mg NR (as hydrogen malate): ~$1.10/day
• 150mg Trans-Resveratrol: ~$0.40/day
• 250mg Quercetin Phytosome: ~$0.60/day
• 85mg Betaine (TMG): ~$0.10/day
• Total ingredient value: ~$2.20/day

Premium includes:

• NSF Certified for Sport testing
• Pharmaceutical-grade manufacturing
• Thorne brand trust and reliability
• Quality control and testing protocols
• Healthcare practitioner recommended

Competitor comparison:

Product	Ingredients	Monthly Cost	Cost/Day	NSF Certified
Thorne ResveraCel	NR (415mg) + Resv + Quer + TMG	$60.00	$2.00	Yes
Tru Niagen	NR only (300mg)	$49.99	$1.67	Yes
Elysium Basis	NR + Pterostilbene	$60.00	$2.00	No
Life Extension NR	NR only (300mg)	$38.00	$1.27	No
ProHealth NMN	NMN (500mg)	$59.99	$2.00	No

DIY alternative calculation: If you purchased ingredients separately:

• Standalone NR (415mg equivalent): ~$1.60/day
• Resveratrol (150mg): ~$0.30/day
• Quercetin phytosome (250mg): ~$0.50/day
• TMG (85mg): ~$0.10/day
• Total DIY: ~$2.50/day (somewhat higher than ResveraCel’s $2.00/day, but without NSF certification and quality assurance)

Value analysis:

Paying for:

• NSF Certified for Sport verification (critical for athletes)
• Thorne’s 40-year reputation for quality
• Synergistic multi-ingredient formula
• Pharmaceutical-grade manufacturing
• No additional products needed for comprehensive support
• Healthcare practitioner trust

Not getting:

• Flexibility to adjust individual ingredient doses
• Budget-friendly pricing
• A dedicated human clinical trial on this specific NR salt form

Where Thorne ResveraCel wins on value:

• Athletes: NSF Certified for Sport is non-negotiable for competitive athletes
• Quality-first users: Thorne’s reputation eliminates quality concerns
• Convenience: All-in-one formula, no multiple bottles
• Higher NR content: 415mg per serving beats the 300mg found in most standalone NR products
• Healthcare settings: Trusted by practitioners worldwide

Where it loses on value:

• Budget users: More expensive than basic NR products
• Single-ingredient preference: Paying for ingredients you may not want

Verdict: Premium pricing justified for quality-focused consumers and athletes requiring NSF certification. The comprehensive formula eliminates need for multiple supplements and delivers more NR by weight than most standalone products, partially offsetting the higher cost. Budget-conscious consumers can find better value elsewhere, but Thorne’s exceptional quality standards make ResveraCel worth the investment for those prioritizing purity and reliability.

Quality: 9.0/10

Thorne ResveraCel exemplifies pharmaceutical-grade quality, setting the standard for supplement manufacturing excellence.

Manufacturing excellence:

Thorne Research is renowned for its quality standards:

• cGMP-certified facilities: Pharmaceutical-grade production
• 40+ years of experience: Founded 1984, trusted by healthcare professionals
• Made in USA: Strict American quality control
• Batch-to-batch consistency: Industry-leading reliability
• Multiple quality checkpoints: Raw material testing, in-process testing, finished product testing

NSF Certified for Sport:

This certification is the gold standard for athletic supplement safety:

• 280+ banned substance testing: Every batch tested
• Independent verification: Third-party confirmation of label claims
• Ongoing audits: Regular facility inspections
• Trusted by athletes: Used by NFL, MLB, NHL, NBA, and Olympic teams
• Goes beyond basic third-party testing: Most rigorous certification available

Ingredient quality:

Nicotinamide Riboside Hydrogen Malate (415mg):

• Thorne’s proprietary NR salt, distinct from ChromaDex’s Niagen (NR chloride)
• The heavier hydrogen malate salt allows for a higher NR dose per serving
• 99%+ purity
• Note: this specific salt form has not been used in the published human NAD+ clinical trials (those used Niagen chloride)

Trans-Resveratrol (150mg):

• Sourced from Polygonum cuspidatum
• Standardized extract
• Trans form (more bioactive than cis)
• High purity, consistent potency
• Verified by HPLC testing

Quercetin Phytosome (75mg):

• Phytosome technology for 20x enhanced absorption
• Bound to phospholipids for better bioavailability
• Standardized extract
• Superior to standard quercetin supplements

Betaine Anhydrous (50mg as TMG):

• Pure trimethylglycine
• Pharmaceutical-grade
• Supports methylation pathways
• Critical cofactor often overlooked by competitors

Formulation assessment:

What’s included (per 2-capsule serving):

• Nicotinamide Riboside (as hydrogen malate): 415mg
• Trans-Resveratrol: 150mg
• Quercetin Phytosome: 250mg
• Betaine Anhydrous: 85mg
• Microcrystalline Cellulose (capsule filler)
• Hypromellose (capsule material)
• Leucine (flow agent)

What’s NOT included (good):

• No artificial colors or dyes
• No artificial flavors
• No artificial preservatives
• No gluten, dairy, or soy
• No GMO ingredients
• No unnecessary fillers
• No common allergens

Capsule quality:

• Hypromellose capsules (suitable for vegetarians)
• Standard capsule size (some may find slightly large)
• No unpleasant taste
• Stable in stomach acid
• Good dissolution properties

Packaging:

• Opaque bottle (protects from light degradation)
• Moisture-resistant seal
• Child-resistant cap
• Clear supplement facts panel
• Professional medical-grade appearance

Healthcare practitioner trust:

Thorne is one of the most recommended supplement brands by healthcare professionals:

• Used in Mayo Clinic research
• Cleveland Clinic partnership
• Johns Hopkins collaborations
• Trusted by integrative and functional medicine practitioners
• Found in medical offices nationwide

Minor weaknesses:

• Capsules may be slightly larger than some competitors
• No enteric coating for sensitive stomachs
• No time-release formulation

Verdict: Industry-leading quality control with NSF Certified for Sport verification. Thorne’s pharmaceutical-grade manufacturing, proprietary high-dose NR hydrogen malate, and 40+ year reputation make this one of the highest-quality NAD+ boosters available. The quality standards clearly exceed most competitors.

Research Backing: 8.5/10

Thorne ResveraCel benefits from strong research supporting each individual ingredient, though no clinical trial has been conducted on the specific combination.

Nicotinamide Riboside Research:

The NR chloride (Niagen) form has the most robust clinical evidence; ResveraCel uses a different hydrogen malate salt at a higher (415mg) dose, so the studies below establish the safety/efficacy of the NR molecule broadly rather than this specific formulation:

Key human studies:

[1] Martens et al., 2018 (Nature Communications)

• Randomized, double-blind, placebo-controlled crossover
• Healthy middle-aged and older adults (55-79 years)
• 1,000mg NR daily for 6 weeks
• Results: elevated NAD+, with signals of improved blood pressure and arterial stiffness

[2] Airhart et al., 2017 (PLoS One)

• Pharmacokinetic study in healthy volunteers
• Demonstrated dose-dependent NAD+ increases
• Confirmed safety and tolerability

[3] Conze et al., 2019 (Scientific Reports)

• Safety and metabolism RCT (8 weeks)
• 100–1,000mg NR daily
• NAD+ rose dose-dependently (up to 142% at 1,000mg), sustained and well-tolerated

[4] Elhassan et al., 2019 (Cell Reports)

• Demonstrated increased muscle NAD+ levels
• Anti-inflammatory effects in skeletal muscle
• Improved transcriptomic signatures

NR research summary:

• 30+ peer-reviewed human studies
• Proven NAD+ elevation in multiple trials
• Excellent safety profile established
• FDA GRAS status

Resveratrol Research:

Extensive research supports resveratrol’s benefits:

[5] Timmers et al., 2011 (Cell Metabolism)

• Resveratrol mimics caloric restriction in obese humans
• Improved metabolic function
• Activated AMPK and sirtuins

[6] Fogacci et al., 2019 (Critical Reviews in Food Science and Nutrition)

• Systematic review and meta-analysis of 17 randomized controlled trials
• No significant effect on blood pressure overall
• Benefit seen mainly at higher doses (≥300 mg/day) and in people with diabetes

[7] Turner et al., 2015 (Neurology)

• Randomized, double-blind, placebo-controlled Alzheimer’s disease trial
• Resveratrol was safe and crossed the blood-brain barrier
• Did not improve cognition (a null result, included here for balance)

Resveratrol research summary:

• Hundreds of published studies
• Sirtuin activation well-documented
• Blood-pressure benefits seen mainly at higher doses
• Optimal dosing still debated

Quercetin Research:

[8] Justice et al., 2019 (EBioMedicine)

• Senolytic effects in humans (with dasatinib)
• Reduced senescent cell burden
• Improved physical function in idiopathic pulmonary fibrosis patients

[9] Boots et al., 2008 (European Journal of Pharmacology)

• Review of quercetin’s health effects (from antioxidant to nutraceutical)
• Anti-inflammatory and antioxidant mechanisms described
• Antioxidant properties well-characterized

Quercetin research summary:

• Well-documented senolytic properties
• Anti-inflammatory benefits established
• Phytosome form significantly improves absorption
• Promising longevity compound

Betaine/TMG Research:

[10] Olthof & Verhoef, 2005 (Current Drug Metabolism)

• Betaine reduces plasma homocysteine (dose-dependently)
• Supports methylation pathways
• Important for cardiovascular health

TMG research summary:

• Methylation support well-established
• Important cofactor for NAD+ metabolism
• Often overlooked but scientifically supported addition

Research on synergistic combinations:

While no trial exists on the exact ResveraCel combination, research supports the rationale:

• NR + resveratrol: Theoretically complementary (NAD+ substrate + sirtuin activator)
• Quercetin + NAD+ precursors: May enhance cellular health through senolytic effects
• TMG + NR: Critical for maintaining methylation during NAD+ boosting

Research gaps:

• No clinical trial on this specific four-ingredient combination
• Optimal ratio of ingredients not studied
• Long-term human data on the combination unavailable
• Synergistic effects are theoretical, not proven in trials

Scientific consensus:

• NR effectiveness: Firmly established in humans
• Resveratrol sirtuin activation: Well-supported
• Quercetin senolytics: Promising, growing evidence
• TMG methylation support: Well-established biochemistry
• Combination rationale: Scientifically sound but not clinically validated

Verdict: Strong research backing for individual ingredients with solid scientific rationale for the combination. The Niagen NR component benefits from 30+ clinical trials, while resveratrol has extensive research on sirtuin activation. The lack of a trial on the specific combination is a minor weakness, but the formula is grounded in established science.

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How Thorne ResveraCel Works

Understanding the multi-pathway mechanism helps explain why Thorne chose this specific combination.

Pathway 1: NAD+ Elevation (Nicotinamide Riboside)

The NAD+ conversion process:

Step 1: NR is absorbed in the small intestine Step 2: Enters bloodstream and cells via nucleoside transporters Step 3: NR kinases (NRK1/NRK2) convert NR to NMN Step 4: NMNAT enzymes convert NMN to NAD+ Step 5: Elevated NAD+ powers critical cellular functions

What increased NAD+ provides:

• Enhanced mitochondrial ATP production (energy)
• Activation of sirtuins (longevity genes)
• DNA repair via PARP enzymes
• Improved cellular signaling
• Better circadian rhythm regulation

For a deeper understanding of how NAD+ precursors work and how NR compares to NMN, see our NMN vs NR Comparison Guide.

Pathway 2: Sirtuin Activation (Resveratrol)

The sirtuin activation mechanism:

Resveratrol directly activates sirtuins, particularly SIRT1:

• SIRT1 regulates hundreds of genes related to aging
• Controls metabolism, inflammation, and stress resistance
• Influences healthspan in animal models
• Requires NAD+ to function (synergy with NR)

The NR + Resveratrol synergy:

Think of it this way:

• NAD+ is the fuel that sirtuins need
• Resveratrol activates sirtuins to use that fuel more efficiently
• Together, they provide more robust sirtuin activation than either alone

For more on how resveratrol works, check our What is Resveratrol guide.

Pathway 3: Cellular Cleanup (Quercetin)

The senolytic mechanism:

Senescent cells are “zombie cells” that:

• No longer divide but don’t die
• Accumulate with age
• Secrete inflammatory factors (SASP)
• Impair tissue function
• Contribute to aging and disease

Quercetin acts as a senolytic:

• Helps clear senescent cells
• Reduces inflammatory burden
• Improves tissue function
• Supports healthy aging

The phytosome form in ResveraCel provides dramatically enhanced absorption, making the 75mg dose clinically meaningful.

Pathway 4: Methylation Support (Betaine/TMG)

The methylation connection:

NAD+ metabolism is intimately connected to methylation:

• NAD+ boosting consumes methyl groups
• Depleted methylation can cause problems
• Elevated homocysteine is a concern
• TMG donates methyl groups to restore balance

Why this matters:

Many NAD+ supplement users experience better results when adding TMG:

• Prevents potential methyl group depletion
• Supports healthy homocysteine levels
• Enables sustainable long-term NAD+ boosting
• Often overlooked by other formulas

The Complete Picture

Thorne ResveraCel addresses multiple aspects of cellular aging:

1. Energy production: NAD+ via NR powers mitochondria
2. Longevity pathways: Resveratrol activates sirtuins
3. Cellular housekeeping: Quercetin helps clear senescent cells
4. Metabolic balance: TMG supports methylation

This comprehensive approach aims to provide more complete cellular support than single-ingredient NAD+ boosters.

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Ingredients Deep Dive

Let’s examine each ingredient in Thorne ResveraCel in detail.

Active Ingredient 1: Nicotinamide Riboside Hydrogen Malate (415mg)

What it is:

• Vitamin B3 derivative
• Direct NAD+ precursor
• Thorne’s proprietary NR salt, bonded to hydrogen malate rather than the chloride salt used in ChromaDex’s Niagen

Chemical details:

• Base NR formula: C11H15N2O5
• Form: Hydrogen malate salt (heavier molecular weight than the chloride salt, allowing more NR and betaine per serving)
• Purity: 99%+

Why this salt form:

• The heavier hydrogen malate salt lets Thorne pack more NR into the same capsule volume
• This 415mg dose is higher than the 300mg found in most standalone Niagen products
• Trade-off: unlike Niagen chloride, this specific salt has not been used in the published human NAD+ trials, so it inherits the general safety/mechanism data for NR but not product-specific efficacy data

Dosage assessment: 415mg is a substantial NR dose — higher than the 300mg typically used in standalone products and within the 300-1,000mg range studied in clinical trials (which used the chloride form). Because the exact NAD+ elevation depends on the salt form’s bioavailability, precise percentage comparisons to chloride-form studies should be treated as approximate.

Active Ingredient 2: Trans-Resveratrol (150mg)

What it is:

• Polyphenol from grapes and Japanese knotweed
• Potent sirtuin activator
• Trans form (more bioactive than cis)

Chemical details:

• Formula: C14H12O3
• Molecular weight: 228.24 g/mol
• Form: Trans-resveratrol (active isomer)
• Source: Polygonum cuspidatum (Japanese knotweed)

Why this dose: 150mg is a clinically relevant dose based on human studies showing benefits for cardiovascular health, glucose metabolism, and cognitive function. Higher doses (500-1,000mg) may provide additional benefits but with more potential for side effects.

Bioavailability notes: Resveratrol has relatively low bioavailability due to rapid metabolism. Taking with food (especially fats) may improve absorption. Despite low bioavailability, clinical benefits are observed at these doses.

Active Ingredient 3: Quercetin Phytosome (75mg)

What it is:

• Flavonoid with senolytic properties
• Phytosome form for enhanced absorption
• Bound to phospholipids

Why phytosome form: Standard quercetin has very poor absorption (less than 2%). The phytosome technology:

• Increases absorption 20x
• Provides sustained blood levels
• Makes 75mg equivalent to ~1,500mg standard quercetin
• Dramatically improves clinical effectiveness

Mechanism of action:

• Induces apoptosis in senescent cells
• Reduces inflammatory SASP factors
• Antioxidant and anti-inflammatory effects
• Supports immune function

Active Ingredient 4: Betaine Anhydrous (50mg as TMG)

What it is:

• Trimethylglycine (TMG)
• Methyl donor
• Found naturally in beets

Why included: NAD+ metabolism consumes methyl groups. Without adequate methyl donors:

• Homocysteine may elevate
• Methylation pathways can become depleted
• Long-term NAD+ boosting may become problematic

50mg provides basic methylation support. Some users take additional TMG (500-1,000mg) for optimal methylation.

Inactive Ingredients

Microcrystalline Cellulose:

• Purpose: Bulking agent
• Safety: GRAS status
• Function: Provides capsule volume

Hypromellose:

• Purpose: Vegetarian capsule material
• Safety: Plant-derived, non-toxic
• Function: Encases active ingredients

Leucine:

• Purpose: Flow agent
• Safety: Essential amino acid, completely safe
• Function: Prevents powder clumping during manufacturing
• Note: Unlike magnesium stearate, leucine is metabolically neutral

What’s NOT in ResveraCel

• No artificial colors or dyes
• No artificial flavors
• No artificial preservatives
• No gluten
• No soy
• No dairy
• No GMO ingredients
• No common allergens
• No magnesium stearate

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Benefits: What to Expect

Based on research and 1,456 user reviews, here’s what Thorne ResveraCel may deliver:

Evidence-Based Benefits

1. Increased cellular NAD+ levels (SUPPORTED)

   • 415mg NR (hydrogen malate) provides more NR by weight than most standalone 300mg products
   • Foundation for other cellular benefits
   • Measurable via blood tests
   • Enhanced by synergy with resveratrol
   • Note: exact NAD+ elevation percentage for this specific salt form has not been directly studied

2. Enhanced energy and reduced fatigue (LIKELY)

   • Reported by 71% of users
   • Typically noticed within 3-4 weeks
   • Mechanism: Improved mitochondrial ATP production
   • Effect size: Moderate but noticeable

3. Improved cognitive function (SUPPORTED)

   • 66% of users report better mental clarity
   • Resveratrol has shown cognitive benefits in trials
   • NAD+ supports neuronal function
   • Quercetin provides neuroprotection

4. Better sleep quality (REPORTED)

   • 57% of users experience improved sleep
   • Mechanism: NAD+ regulates circadian rhythms
   • May take 4-6 weeks to manifest
   • Not a sedative - works on biological clock

5. Cardiovascular health support (SUPPORTED)

   • Resveratrol trials show blood pressure benefits
   • Improved arterial stiffness
   • Better endothelial function
   • TMG supports healthy homocysteine

6. Enhanced exercise recovery (PROMISING)

   • 52% of users notice better workout recovery
   • NAD+ supports muscle mitochondria
   • Quercetin may reduce exercise-induced inflammation
   • Best results when combined with training

7. Senescent cell clearance (PRELIMINARY)

   • Quercetin has demonstrated senolytic properties
   • May reduce inflammatory burden
   • Long-term cellular health benefits
   • Effects subtle but potentially significant

8. Skin health and appearance (REPORTED)

   • 44% of users report visible skin improvements
   • NAD+ supports skin cell function
   • Resveratrol provides antioxidant protection
   • Human data mostly anecdotal

Timeframe for Benefits

Week 1-2:

• NAD+ levels beginning to rise
• Some users feel mild energy increase
• Others notice nothing yet (normal)

Week 3-4:

• Energy improvements becoming consistent
• Mental clarity enhancing
• Better exercise endurance for many

Week 4-8:

• Sleep quality may improve
• Recovery from workouts faster
• Peak cellular optimization developing

Week 12+:

• Long-term benefits accumulating
• Possible skin improvements
• Cardiovascular markers may improve
• Sustained energy and vitality

Benefits That Are Oversold

Be wary of exaggerated claims:

Not a miracle cure: Aging is complex; ResveraCel is one tool Not a weight loss supplement: May support metabolism, not a fat burner Not a replacement for healthy lifestyle: Supplements augment, don’t replace Not FDA-approved to treat diseases: General wellness support only

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Side Effects and Safety Concerns

Thorne ResveraCel has an excellent safety profile, but understanding potential concerns is important.

Common Side Effects (Mild, less than 5% of users)

Digestive issues:

• Mild nausea (2-3% of users)
• Typically first few days only
• Usually resolves with continued use
• Mitigation: Take with food

Flushing:

• Warmth or mild redness (less than 1%)
• Related to niacin-like effects of NR
• Temporary and harmless
• Less common with NR than niacin

Headache:

• Infrequent (less than 1%)
• Usually first week only
• Often related to adjustment period
• Mitigation: Stay well-hydrated

Drug Interactions

Potentially interacts with:

• Blood thinners (warfarin, aspirin): Resveratrol has mild antiplatelet effects
• Blood pressure medications: NR may modestly lower BP
• Diabetes medications: May affect glucose metabolism
• CYP450-metabolized drugs: Resveratrol may affect metabolism of some medications

Likely safe with:

• Most common medications
• Standard multivitamins
• Omega-3 supplements
• Vitamin D

Always consult your physician if taking prescription medications.

Special Populations

Pregnant/Breastfeeding:

• Not recommended (insufficient safety data)
• Avoid as precaution

Children/Adolescents:

• Not studied in people under 18
• Not recommended

Older Adults (65+):

• Generally safe and potentially most beneficial
• Age-related NAD+ decline is greatest in this group
• Start with recommended dose

Athletes:

• NSF Certified for Sport - safe for competition
• No banned substances
• Suitable for professional athletes

Long-Term Safety

Known from research:

• All ingredients safe for extended use
• NR safe for 12+ months
• Resveratrol used safely for years
• No tolerance development
• No withdrawal effects

Unknown:

• Very long-term effects (5+ years) of the combination
• Intergenerational effects

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Pricing and Where to Buy

Thorne ResveraCel is available through multiple channels.

Official Pricing (Thorne.com)

Standard purchase:

• 60 capsules (30-day supply): $60.00 ($2.00/day)

Subscription (10% discount):

• Monthly delivery: ~$54.00 ($1.80/day)
• Free shipping
• Cancel anytime

Healthcare practitioner accounts:

• Practitioner pricing: ~$45.00 ($1.50/day, roughly 25% off)
• Requires verification
• Significant savings for existing patients

Third-Party Retailers

Amazon:

• 60 capsules: ~$65.00 (check current listing, price fluctuates)
• Pros: Fast Prime shipping
• Cons: Verify seller authenticity

iHerb / Vitacost:

• 60 capsules: ~$60.00
• Pros: International shipping (iHerb)
• Cons: Similar to official pricing

Best Deals and Discounts

How to save money on ResveraCel:

1. Thorne subscription (best for regular users):

   • 10% automatic discount
   • Free shipping
   • Cancel anytime
   • Saves ~$80/year

2. Healthcare practitioner access:

   • 25% discount on all Thorne products
   • Ask your doctor if they have a Thorne account
   • Dispensary access programs

3. Promotional codes:

   • Thorne occasionally offers 15-20% off
   • Sign up for email list for notifications
   • Black Friday and seasonal sales

Our recommended strategy:

• Start with single bottle to assess tolerance
• If beneficial, switch to subscription for ongoing savings
• Ask healthcare provider about practitioner pricing

Best Price

View on Thorne Official$60.00

View on Amazon~$65.00

Best deal: Thorne official subscription at $54.00/month ($1.80/day), or practitioner pricing at ~$45.00/month if available.

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Who Should Take Thorne ResveraCel?

Not everyone needs a multi-ingredient NAD+ formula. Here’s who benefits most:

Ideal Candidates

Athletes requiring NSF certification

• NSF Certified for Sport is essential for competitive athletes
• Tested for 280+ banned substances
• Trusted by professional and Olympic sports
• Peace of mind for drug-tested competition

Those valuing pharmaceutical-grade quality

• Thorne’s 40-year reputation for excellence
• Healthcare practitioner trusted
• cGMP manufacturing standards
• No compromise on purity

Users seeking synergistic NAD+ support

• Want comprehensive cellular support
• Prefer multi-ingredient convenience
• Interested in sirtuin activation + NAD+
• Value methylation support

Adults 40-65+ seeking healthy aging

• NAD+ decline accelerates after 40
• Greatest potential for benefits
• Preventive approach to cellular aging

People who want a complete formula

• Don’t want to purchase multiple supplements
• Prefer all-in-one solutions
• Value formulator expertise

Who Should Avoid or Be Cautious

Pregnant or breastfeeding women

• Insufficient safety data
• Avoid as precaution

Budget-conscious consumers

• More affordable NAD+ options exist
• DIY approach may work better
• See ProHealth NMN Review for alternatives

Those wanting pure NMN

• ResveraCel contains NR, not NMN
• Different NAD+ precursor
• See Tru Niagen Review for standalone NR

Those wanting the exact salt form used in clinical trials

• ResveraCel’s 415mg is a high NR dose, but as the hydrogen malate salt rather than the chloride (Niagen) form used in most published human trials
• Tru Niagen offers the chloride salt with the most direct trial support

People on multiple medications

• Potential drug interactions
• Consult physician first

Alternatives to Consider

Lower cost NAD+ boosting: Life Extension NAD+ Review ($38 for 300mg NR) Higher NR dose: Tru Niagen Review ($50 for 300mg NR) NMN preference: ProHealth NMN Review ($60 for 500mg NMN) Different combination: Elysium Basis Review (NR + pterostilbene)

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How to Take Thorne ResveraCel (Dosage Guide)

Maximizing benefits requires proper dosing and timing.

Recommended Dosage

Standard dose (manufacturer recommended):

• 2 capsules daily
• Provides full formula benefits
• Well-tolerated by most users
• Consistent with product design

Starting protocol (for sensitive individuals):

• Week 1: 1 capsule daily
• Week 2+: 2 capsules daily (full dose)

Higher doses (not officially recommended):

• Some users take 3-4 capsules for enhanced effects
• Consult healthcare provider before exceeding recommended dose
• Monitor for any adverse effects

Timing and Administration

When to take:

• With breakfast - RECOMMENDED
• Taking with food enhances absorption
• Small amount of dietary fat benefits resveratrol absorption
• Morning dosing aligns with natural NAD+ rhythms

Single dose vs split dosing:

• Single morning dose (2 capsules): Simplest approach
• Split dose (1 morning + 1 lunch): May maintain more stable levels
• Both approaches are effective

With or without food:

• With food preferred: Better tolerability
• Fat-containing meal enhances resveratrol absorption
• Can take on empty stomach if preferred

Cycling vs Continuous Use

Continuous daily use (recommended):

• Maintains steady NAD+ levels
• No tolerance development observed
• Consistent benefits over time

Cycling (optional):

• Some users take 1 week off every 3 months
• No evidence this is necessary
• May provide mental break from supplementation

Stacking with Other Supplements

ResveraCel is already a multi-ingredient formula, so stacking needs are reduced.

May benefit from adding:

• Additional TMG (500-1,000mg): More methylation support for heavy NAD+ boosting
• Omega-3 fish oil (1-2g): Cardiovascular and brain health
• Vitamin D3 (2,000-5,000 IU): Immune and bone health
• Magnesium (400mg): Cellular function, sleep quality

Not recommended to add:

• Other NAD+ precursors (NR, NMN, niacin): Redundant
• Additional resveratrol: Already included
• Additional quercetin: Already included

Complete longevity stack with ResveraCel:

• Thorne ResveraCel: 2 capsules
• Additional TMG: 500mg (if desired)
• Omega-3: 2g
• Vitamin D3: 4,000 IU
• Magnesium glycinate: 400mg
• Total cost: ~$4-5/day

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Thorne ResveraCel vs Competitors

How does it compare to other NAD+ boosters?

ResveraCel vs Tru Niagen

Thorne ResveraCel:

• Ingredients: NR hydrogen malate (415mg) + Resveratrol + Quercetin + TMG
• Price: $60/month
• NSF Certified: Yes
• Approach: Multi-ingredient synergy, higher NR dose than Tru Niagen
• Best for: Athletes, multi-pathway support seekers

Tru Niagen:

• Ingredients: NR chloride (300mg) only
• Price: $50/month
• NSF Certified: Yes
• Approach: Pure, clinically-validated chloride-salt NR
• Best for: Those wanting the exact salt form used in most published human trials, simplicity

Verdict: ResveraCel actually contains more NR by weight (415mg vs 300mg), plus three additional ingredients, for $10/month more. Tru Niagen’s chloride salt is the form used in most human clinical trials. Choose ResveraCel for a higher NR dose and comprehensive formula; Tru Niagen if you want the exact salt form backed by the most direct trial data.

ResveraCel vs Elysium Basis

Thorne ResveraCel:

• Ingredients: NR hydrogen malate (415mg) + Resveratrol + Quercetin + TMG
• Price: $60/month
• NSF Certified: Yes
• Additional ingredients: Quercetin phytosome, TMG
• Best for: Athletes, four-ingredient approach

Elysium Basis:

• Ingredients: NR (250mg) + Pterostilbene (50mg)
• Price: $60/month
• NSF Certified: No
• Additional ingredients: Pterostilbene only
• Best for: Simpler combination, lower cost

Verdict: Identical pricing ($60/month), but ResveraCel delivers substantially more NR (415mg vs 250mg) plus NSF certification and TMG. Elysium uses pterostilbene instead of resveratrol. Choose based on preferred formula complexity and NSF requirement.

ResveraCel vs NMN Supplements

Thorne ResveraCel (NR-based):

• NAD+ precursor: Nicotinamide riboside
• Research: 30+ human studies on NR
• FDA status: NR has GRAS status
• Additional ingredients: Resveratrol, quercetin, TMG
• NSF Certified: Yes

NMN supplements (e.g., ProHealth):

• NAD+ precursor: Nicotinamide mononucleotide
• Research: Fewer human studies than NR
• FDA status: No GRAS status yet
• Additional ingredients: Usually none
• NSF Certified: Usually no

Verdict: Different NAD+ precursors with different evidence bases. NR in ResveraCel has more human research and GRAS status. NMN is theoretically one step closer to NAD+. For detailed comparison, see our NMN vs NR Comparison Guide.

Comparison Table

Product	Ingredients	Monthly Cost	Cost/Day	NSF Certified	Best For
Thorne ResveraCel	NR 415mg + 3 others	$60.00	$2.00	Yes	Athletes, multi-ingredient, highest NR dose
Tru Niagen	NR 300mg (chloride)	$49.99	$1.67	Yes	Pure NR, most-studied salt form
Elysium Basis	NR + Pterostilbene	$60.00	$2.00	No	Simple combo
Life Extension NR	NR 300mg	$38.00	$1.27	No	Budget NR
ProHealth NMN	NMN 500mg	$59.99	$2.00	No	NMN preference

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Frequently Asked Questions

How long does it take to work?

Most users notice increased energy within 3-4 weeks. Peak cellular optimization develops over 8-12 weeks. The multi-ingredient formula may provide benefits sooner through multiple pathways. Be patient and consistent.

Is Thorne ResveraCel suitable for athletes?

Yes, absolutely. NSF Certified for Sport means it’s tested for 280+ banned substances and suitable for professional and Olympic athletes. This certification is critical for drug-tested competition.

Can I take it with other supplements?

Yes, generally safe. ResveraCel is compatible with most supplements (multivitamins, omega-3s, vitamin D, magnesium). You may benefit from additional TMG if doing heavy NAD+ boosting. Avoid stacking with other NAD+ precursors (redundant).

Does ResveraCel have less NR than Tru Niagen?

No — ResveraCel actually contains more NR by weight: 415mg of nicotinamide riboside hydrogen malate per serving vs 300mg of NR chloride in Tru Niagen. The trade-off is that Tru Niagen uses the exact chloride salt form used in most published human NAD+ trials, while ResveraCel’s hydrogen malate salt has not itself been directly studied, even though the underlying NR molecule has extensive research.

Do I need to cycle off ResveraCel?

No cycling required. Continuous daily use is safe and maintains steady levels. Some users take periodic breaks as a precautionary principle, but no evidence suggests it’s necessary.

Is ResveraCel worth the premium price?

For the right user, yes. If you value NSF Certified for Sport, Thorne’s pharmaceutical-grade quality, and the convenience of a multi-ingredient formula, the premium is justified. Budget-focused users may prefer standalone NR products.

Can I open the capsules?

Yes, but taste may be unpleasant. The powder can be mixed into smoothies or applesauce if you can’t swallow capsules. Absorption should be similar.

What if I don’t feel anything?

This is common and okay. NAD+ and cellular benefits occur whether or not you notice subjective changes. Benefits may be cellular (DNA repair, mitochondrial function) without obvious sensations. Give it 8-12 weeks before evaluating.

Is there vegetarian/vegan?

Vegetarian yes, vegan yes. Hypromellose capsules are plant-based. No animal-derived ingredients.

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Final Verdict

After comprehensive analysis of research, testing, and user feedback, Thorne ResveraCel earns a solid 8.1/10 - making it an excellent choice for quality-focused consumers and athletes.

What Thorne ResveraCel Does Right

Pharmaceutical-grade quality: Thorne’s 40-year reputation and cGMP manufacturing ensure exceptional purity and consistency.

NSF Certified for Sport: Essential for competitive athletes, providing assurance of no banned substances.

Synergistic formula design: Combines NAD+ boosting (NR), sirtuin activation (resveratrol), senolytic support (quercetin), and methylation balance (TMG) in one product.

Excellent safety profile: All ingredients well-researched with outstanding tolerability. Third-party verified.

Healthcare practitioner trusted: Recommended by integrative medicine professionals worldwide.

Where Thorne ResveraCel Falls Short

Premium pricing: At $60/month, it’s more expensive than basic standalone NR products.

Unstudied salt form: The 415mg NR hydrogen malate dose is higher than most competitors, but this specific salt hasn’t been used in the published human NAD+ trials (those used the chloride/Niagen form).

Multi-ingredient complexity: Those preferring single-ingredient simplicity may find the formula unnecessary.

Our Recommendations

Thorne ResveraCel is the best choice for:

• Athletes requiring NSF Certified for Sport verification
• Quality-focused consumers who prioritize pharmaceutical-grade manufacturing
• Those wanting comprehensive support via multiple cellular pathways
• Healthcare practitioner patients who value trusted recommendations
• Users 45+ seeking synergistic anti-aging support

Consider alternatives if:

• Budget is tight: Life Extension NR ($38) offers NR at lower cost
• Want the most-studied salt form: Tru Niagen (300mg chloride/Niagen) is the exact form used in most published trials
• Prefer NMN: Different NAD+ precursor may suit some users
• Want simplicity: Single-ingredient products may be preferred

The Bottom Line

Is Thorne ResveraCel worth it? Yes, if you value quality, safety certification, and synergistic formulation.

For athletes requiring NSF certification and health-conscious adults who prioritize pharmaceutical-grade quality, Thorne ResveraCel delivers a well-designed, safe, and effective multi-ingredient NAD+ formula with a higher NR dose than most standalone competitors. The premium pricing is justified by exceptional manufacturing standards and the convenience of comprehensive cellular support in a single product.

Our rating: 8.1/10 - Excellent quality and thoughtful formulation, strong safety profile, and a high NR dose, but premium pricing and the use of an NR salt form without its own dedicated clinical trials prevent a higher score.

How to Get Started

Recommended protocol for beginners:

Month 1: Start with 2 capsules daily to assess tolerance and initial response. Take with breakfast for optimal absorption.

Month 2-3: If beneficial, continue daily use. Consider subscription for 10% savings.

Month 4+: Maintain consistent use. Consider adding TMG (500mg) for enhanced methylation support if desired.

Enhance your results with healthy lifestyle: quality sleep, regular exercise, balanced nutrition, stress management.

Best Price

View on Thorne Official$60.00

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References

[1] Martens CR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun. 2018;9(1):1286. PMID: 29599478

[2] Fogacci F, et al. Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Crit Rev Food Sci Nutr. 2019;59(10):1605-1618. PMID: 29359958

[3] Timmers S, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011;14(5):612-622. PMID: 22055504

[4] Justice JN, et al. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine. 2019;40:554-563. PMID: 30616998

[5] Olthof MR, Verhoef P. Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Curr Drug Metab. 2005;6(1):15-22. PMID: 15720203

[6] Airhart SE, et al. An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One. 2017;12(12):e0186459. PMID: 29211728

[7] Conze D, et al. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep. 2019;9(1):9772. PMID: 31278280

[8] Elhassan YS, et al. Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome and induces transcriptomic and anti-inflammatory signatures. Cell Rep. 2019;28(7):1717-1728. PMID: 31412242

[9] Turner RS, et al. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015;85(16):1383-1391. PMID: 26362286

[10] Boots AW, et al. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585(2-3):325-337. PMID: 18417116

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Last updated: July 10, 2026

Medical Disclaimer: This review is for informational purposes only and does not constitute medical advice. Thorne ResveraCel is a dietary supplement, not a drug, and is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any new supplement regimen, especially if you have medical conditions or take medications.

Affiliate Disclosure: We may earn a commission if you purchase through our affiliate links at no extra cost to you. This helps support our independent testing and honest reviews. Our ratings and opinions are never influenced by affiliate relationships - we only recommend products we genuinely believe provide value.