Best NAD+ Supplements 2025
We tested 16 NAD+ boosting supplements including NMN, NR, and combination formulas. Here are the top products ranked by effectiveness, safety, value, and research backing.
ProHealth NMN Pro 500
by ProHealth Longevity
ProHealth NMN Pro 500 review: Expert analysis of this high-purity NMN supplement with clinical research, effectiveness data, safety profile, and real
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Why NAD+ Matters for Longevity
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every cell of your body. It plays essential roles in energy metabolism, DNA repair, and cellular signaling pathways linked to aging.
Research shows that NAD+ levels decline significantly with age - by up to 50% between ages 40 and 60. This decline is associated with many hallmarks of aging, including mitochondrial dysfunction, increased inflammation, and impaired DNA repair. Learn more in our comprehensive guide on how to boost NAD+ naturally.
Key Research Findings
- NAD+ and Aging: A 2016 study in Cell Metabolism demonstrated that declining NAD+ levels contribute to age-related metabolic dysfunction.
- NMN in Humans: A 2021 clinical trial published in Science showed NMN supplementation improved muscle insulin sensitivity in prediabetic women.
- NR Safety: Multiple studies including this 2018 Nature Communications paper confirm NR safely elevates NAD+ in humans.
The good news? NAD+ precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) can effectively restore NAD+ levels. Both have shown promise in human clinical trials for improving various markers of cellular health and metabolism.
Quick Comparison: Best NAD+ Supplements 2025
| Rank | Product | Type | Score | Best For | Price |
|---|---|---|---|---|---|
| 1 | ProHealth NMN Pro 500 ProHealth Longevity
Editor's Choice
| NMN | 8.5 /10 | NAD+ restoration for ages 40+ | $59.99 |
| 2 | DoNotAge NMN Powder DoNotAge
Editor's Choice
| NMN | 8.4 /10 | Budget-conscious biohackers seeking maximum value | $39.99 |
| 3 | Thorne NicotinamidePro Thorne | NAD+ | 8.4 /10 | Quality-focused users | $55.00 |
| 4 | Alive By Science Sublingual NMN Alive By Science | NMN | 8.3 /10 | Biohackers seeking maximum NMN bioavailability | $64.99 |
| 5 | Jarrow Formulas Nicotinamide Mononucleotide (NMR) Jarrow Formulas | NR | 8.3 /10 | Budget-conscious consumers seeking quality NAD+ support | $39.99 |
| 6 | Tru Niagen ChromaDex | NR | 8.3 /10 | NAD+ restoration for ages 40+ | $49.99 |
| 7 | Life Extension NAD+ Cell Regenerator Life Extension
Editor's Choice
| NR | 8.2 /10 | Budget-conscious NAD+ seekers | $38.00 |
| 8 | Renue By Science Liposomal NMN Renue By Science | NMN | 8.2 /10 | Those prioritizing bioavailability | $64.95 |
| 9 | Wonderfeel Youngr NMN Wonderfeel | NMN | 8.2 /10 | Users seeking comprehensive all-in-one longevity formula | $88.00 |
| 10 | Elysium Basis Elysium Health | NR | 8.1 /10 | NAD+ restoration for ages 40+ | $60.00 |
| 11 | Thorne ResveraCel Thorne | NR | 8.1 /10 | Athletes requiring NSF certification | $66.00 |
| 12 | OMRE NMN + Resveratrol OMRE | NMN | 8.0 /10 | Users wanting NMN + resveratrol combination | $47.00 |
| 13 | Quicksilver Scientific NAD+ Gold Quicksilver Scientific | NMN | 8.0 /10 | Those prioritizing absorption | $75.00 |
| 14 | NiaCel 400 Thorne | NR | 8.0 /10 | Longevity enthusiasts wanting comprehensive NAD+ and sirtuin support | $65.00 |
| 15 | Cymbiotika Liposomal NMN Cymbiotika | NMN | 7.9 /10 | Users preferring liquid over capsules/powder | $77.77 |
| 16 | NAD+ Cell Regenerator Life Extension | NR | 7.8 /10 | Budget-conscious users seeking quality NR | $38.00 |
NMN vs NR: Which NAD+ Precursor Is Better?
NMN (Nicotinamide Mononucleotide)
- One step closer to NAD+ in biosynthesis pathway
- Recent discovery of direct cellular uptake via SLC12A8 transporter
- Growing human clinical trial data
- Often better value per effective dose
Best for: Users seeking cutting-edge formulas and potentially faster NAD+ elevation
NR (Nicotinamide Riboside)
- 30+ published human clinical studies
- FDA GRAS (Generally Recognized as Safe) status
- Proven NAD+ elevation of 40-60% in trials
- NSF Certified for Sport options available
Best for: Users prioritizing research backing and regulatory approval
Bottom line: Both NMN and NR effectively boost NAD+ levels. NR has more extensive human research, while NMN may offer advantages in bioavailability. For a detailed breakdown, read our NMN vs NR comparison guide.
Best NMN Supplements
Top-rated NMN products for NAD+ boosting, ranked by our testing methodology.
ProHealth NMN Pro 500
BEST NMNProHealth Longevity
DoNotAge NMN Powder
DoNotAge
Alive By Science Sublingual NMN
Alive By Science
Renue By Science Liposomal NMN
Renue By Science
Best NR (Nicotinamide Riboside) Supplements
Top-rated NR products backed by clinical research.
Jarrow Formulas Nicotinamide Mononucleotide (NMR)
BEST NRJarrow Formulas
Tru Niagen
ChromaDex
Life Extension NAD+ Cell Regenerator
Life Extension
Elysium Basis
Elysium Health
How to Choose the Right NAD+ Supplement
1. Purity and Testing
Look for products with third-party testing and certificates of analysis (COA). Purity should be 98%+ for NMN and NR. Avoid products without transparent testing.
2. Value Per Dose
Calculate cost per effective dose, not just per bottle. A $60 bottle with 500mg capsules may be better value than a $40 bottle with 250mg capsules.
3. Delivery Method
Sublingual and liposomal formulas may offer better absorption than standard capsules. Powders offer flexibility but require measuring.
4. Research Backing
NR has more published human studies, while NMN research is rapidly expanding. Both show efficacy for raising NAD+ levels.
5. Brand Reputation
Established brands with transparent practices are safer choices. Check for customer reviews, return policies, and company history.
6. Your Goals
Athletes may prefer NSF Certified products. Budget-conscious users should consider powder forms. Those with absorption issues may benefit from sublingual delivery.
Frequently Asked Questions
What is the best NAD+ supplement in 2025?
Is NMN or NR better for boosting NAD+?
How long does it take for NAD+ supplements to work?
What is the optimal dosage for NAD+ supplements?
Are NAD+ supplements safe?
Can you take NAD+ directly instead of precursors?
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Affiliate Disclosure: This page contains affiliate links. We earn a commission on qualifying purchases at no additional cost to you. All products are independently selected and reviewed based on our testing methodology. Read our full disclosure and medical disclaimer.