Clear out zombie cells with science-backed senolytics. We analyzed the top fisetin, quercetin, and combination formulas to help you choose the right senolytic supplement for your longevity goals.
by Life Extension
Clinically-studied theaflavin complex combined with quercetin for comprehensive senolytic support. Designed for once-weekly dosing.
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Senolytics are compounds that selectively eliminate senescent cells - damaged cells that have stopped dividing but refuse to die. Often called "zombie cells," these dysfunctional cells accumulate with age and contribute to chronic inflammation, tissue dysfunction, and accelerated aging.
As we age, our bodies accumulate senescent cells. While cellular senescence originally evolved as a tumor-suppression mechanism, the persistence of these cells becomes problematic. Senescent cells secrete a cocktail of inflammatory molecules called the Senescence-Associated Secretory Phenotype (SASP), which can damage neighboring healthy cells and tissues.
Natural senolytics like fisetin and quercetin offer a more accessible approach than pharmaceutical options. While research is still evolving, these compounds show promise for reducing senescent cell burden with a favorable safety profile. For more on the science of cellular aging, see our guide on how to boost NAD+, another key pathway in longevity.
| Rank | Product | Key Ingredient | Score | Best For | Price |
|---|---|---|---|---|---|
| 1 | Life Extension Senolytic Activator Life Extension TOP PICK | Theaflavins (275mg) | 8.4 /10 | Best overall senolytic formula | $24.00 |
| 2 | DoNotAge Fisetin DoNotAge BEST FISETIN | Fisetin (500mg) | 8.2 /10 | Highest potency fisetin | $39.95 |
| 3 | Thorne Quercetin Phytosome Thorne BEST ABSORPTION | Quercetin Phytosome (250mg) | 8.1 /10 | Enhanced absorption quercetin | $32.00 |
| 4 | NOW Foods Quercetin NOW Foods BEST VALUE | Quercetin (500mg) | 7.9 /10 | Best budget option | $16.99 |
| 5 | Swanson Fisetin Swanson | Fisetin (100mg) | 7.7 /10 | Budget-friendly fisetin | $14.99 |
by Life Extension
by DoNotAge
by Thorne
by NOW Foods
by Swanson
Found in strawberries and apples. Identified as the most potent natural senolytic in Mayo Clinic screening studies.
Typical dose: 500mg-2000mg on senolytic days
Found in onions, apples, and capers. Part of the first human-tested senolytic protocol (with dasatinib).
Typical dose: 500mg-1000mg on senolytic days
For most people: Consider cycling both fisetin and quercetin. Many longevity enthusiasts use quercetin-based protocols (like Life Extension Senolytic Activator) weekly and add high-dose fisetin quarterly. This approach leverages the research behind both compounds. Always start with lower doses and consult a healthcare provider for personalized guidance.
Unlike daily supplements, senolytics work best with intermittent dosing. Once senescent cells are cleared, they stay cleared - you don't need continuous exposure. This is based on the Mayo Clinic's pioneering senolytic research led by Dr. James Kirkland.
Based on human clinical trial protocols:
Note: Dasatinib requires prescription. Natural alternatives use quercetin or fisetin alone.
Based on mouse study protocols (adapted for humans):
Take with fat-containing food for better absorption.
Senolytic effects require adequate doses. Look for fisetin at 500mg+ per capsule or quercetin at 250mg+ (enhanced forms) or 500mg+ (standard quercetin).
Both fisetin and quercetin have poor natural absorption. Look for enhanced forms like quercetin phytosome or take with fats/oils to improve uptake.
Since these are higher-dose protocols, purity matters. Choose products with certificates of analysis (COA) from independent labs verifying potency and absence of contaminants.
Choose established brands with longevity supplement expertise. Life Extension, Thorne, and DoNotAge have strong track records for quality and transparency.
Calculate cost per senolytic "cycle" rather than per capsule. A higher-dose product requiring fewer capsules may offer better value for intermittent protocols.
Some products combine multiple senolytics (e.g., theaflavins + quercetin). These may offer broader action across different cell types.
Based on our analysis, here are our top recommendations for different needs and budgets.
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